Beyond Static Structures: How NMR Spectroscopy Solves Biology’s Toughest Dynamic Problems
Crystallography and cryo-EM require frozen or crystallized samples, leaving flexible proteins, transient interactions, and membrane environments largely invisible. NMR spectroscopy closes this gap. It captures atomic-resolution dynamics in near-physiological conditions, detects weak binders, and characterizes disordered proteins. Modern advances in high-field magnets and isotope labeling have made NMR indispensable for drug discovery. This post explores three powerful approaches, […]
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